Expertise & Technology
We provide a diverse set of leading-edge, mass spectrometry-driven proteomics technologies
The services offered include large-scale differential proteome analysis, mapping of protein modifications and interactions, characterization of isolated protein complexes using affinity purification-mass spectrometry (AP-MS), protein quantification using targeted proteomics, protein mass determination, identification of protein partners binding to drugs or small molecules (chemical proteomics), and, finally comprehensive data analysis and support.
We guide our users from sample collection to data analysis and will assist you in formulating biological conclusions that are easy to interpret for the non-proteomics expert.
Shotgun proteomics
Affinity Purification MS
PTM analysis
Shotgun proteomics
Generates comprehensive proteomic profiles that reveal differences in protein levels associated with a particular cellular state or experimental condition. Samples can be isotopically labelled (e.g. by SILAC or TMT labelling) for optimal quantitation accuracy or sample multiplexing, in addition to the standard label-free approach.
Plasma, serum or CSF proteomics
Generates comprehensive proteomic profiles in biofluids that reveal differences in protein levels associated with a particular treatment or disease.
Post-translational modification analysis
Mapping of common protein post-translational modifications (PTM) such as acetylation, phosphorylation and ubiquitination sites, as well as protease cleavage sites for which the PRC has extensive experience.
Affinity Purification MS (AP-MS)
Allows the characterization of protein complexes and the discovery of novel protein interactions.
Virotrap
Peptide mapping
Mapping the amino acid sequence (and PTMs) of recombinant, purified protein
Protein mass determination
Measures the intact mass of (semi-) purified proteins.
